circRNA basic information
circBase ID: hsa_circ_0023984
Name: -
Synonym: circ_0023984
Host Gene: hsa-miR-134-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ESCC cell lines (EC109, EC9706, KYSE30, KYSEE150, KYSE410), normal esophageal epithelial cell line (SHEE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-134-5p
Biological function: The knockdown of circ_0023984 suppressed cell growth, invasion, and migration in ESCC cells.
Molecular mechanism: Circ_0023984 interacted with hsa-miR-134-5p and inhibited its activity, which promoted the expression of CST4 (Cystatin-S).
Survival: poor
Supported No.:
 1
Description:

Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR-134-5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies.
Other information
Title:

CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis.

Journal: Bioengineered
Published: 2022/4/21
PubMed ID: 35440286