circRNA basic information
circBase ID: -
Name: hsa_circ_CDC6
Synonym: CircCDC6
Host Gene: hsa-miR-3187-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Non-cancerous colonic epithelial cells (HCoEpiC), cancer cell lines (SW480, SW620, HCT116, LOVO)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-3187-3p
Biological function: CircCDC6 ectopic expression repressed CRC cell proliferation, survival and glycolysis energy metabolism
Molecular mechanism: hsa-miR-3187-3p was targeted by circCDC6, and hsa-miR-3187-3p depletion also repressed CRC cell growth and glycolysis. PRKAA2 was a downstream target of circCDC6/hsa-miR-3187-3p pathway, and circCDC6 upregulated PRKAA2 expression via targeting hsa-miR-3187-3p.
Survival: -
Supported No.:
 1
Description:

CircCDC6, acting as a tumor inhibitor, repressed tumor growth and glycolysis metabolism in CRC via targeting the miR-3187-3p/PRKAA2 axis, which partly clarified the role of circCDC6 in CRC.
Other information
Title:

CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2.

Journal: J Bioenerg Biomembr
Published: 2022/4/20
PubMed ID: 35438362