circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: circFAM120B
Host Gene: hsa-miR-661
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (KYSE-150, TE-1), a human embryonic kidney cell line (HEK293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-661
Biological function: Overexpression of circFAM120B inhibited the proliferation, metastasis, and invasion of ESCC while silencing it enhanced malignant phenotypes.
Molecular mechanism: circFAM120B was predominantly located in the cytoplasm, guarantying its sponging for hsa-miR-661 to restore the expression of PPM1L, a tumor suppressor.
Survival: better
Supported No.:
 1
Description:

Our findings suggest that circFAM120B is a promising biomarker of ESCC, which acts as a tumor suppressor via the circFAM120B/miR-661/PPM1L axis and PKR/p38 MAPK/EMT pathway, supporting its significance as a candidate therapeutic target.
Other information
Title:

circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway.

Journal: Cell Death Dis
Published: 2022/4/20
PubMed ID: 35436983