circRNA basic information
circBase ID: -
Name: hsa_circ_XRCC5
Synonym: CircXRCC5,
Host Gene: hsa-miR-490-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: U87, U251 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-490-3p
Biological function: Knockdown of circXRCC5 suppressed cell proliferation, migration and invasion, while facilitated apoptosis.
Molecular mechanism: circXRCC5 acted as a molecular sponge for hsa-miR-490-3p in a sequence-specific manner. There was a reciprocal negative feedback between circXRCC5 and hsa-miR-490-3p in an Argonaute2-dependent manner.
Survival: poor
Supported No.:
 2
Description:

Collectively, circXRCC5 promoted glioma progression via the miR-490-3p/XRCC5/CLC3 ceRNA network, providing a novel prognostic biomarker and a prospective target for glioma treatment.
Other information
Title:

CircXRCC5, as a Potential Novel Biomarker, Promotes Glioma Progression via the miR-490-3p/XRCC5/CLC3 Competing Endogenous RNA Network.

Journal: Neuroscience
Published: 2022/4/19
PubMed ID: 35436516