circRNA basic information
circBase ID: hsa_circ_0067741
Name: -
Synonym: circ_0067741
Host Gene: hsa-miR-183-5p
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LUAD cell lines (Calu-3, A549, H1975, H1299), human normal bronchial epithelial cell (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-183-5p
Biological function: Overexpression of circ_0067741 inhibited the proliferation, migration, invasion, and angiogenesis of LUAD cells and promoted apoptosis.
Molecular mechanism: circ_0067741 could sponge hsa-miR-183-5p to regulate LATS1 expression and then activate the Hippo/YAP pathway.
Survival: better
Supported No.:
 1
Description:

In conclusion, circ_0067741 sponges miR-183-5p, and regulates LATS1 to activate Hippo/YAP pathway, thereby inhibiting the process of LUAD cells. And the circ_0067741/miR-183-5p/LATS1 axis can be a potential target for early diagnosis and targeted treatment of LUAD.
Other information
Title:

Circular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p.

Journal: Bioengineered
Published: 2022/4/19
PubMed ID: 35435136