circRNA basic information
circBase ID: hsa_circ_0000567
Name: hsa_circ_SETD3
Synonym: CircSETD3
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 4947
DO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human intrahepatic bile duct epithelial cells (HiBECs), CCA cell lines (HUCCT1, TFK1, QBC939)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-421
Biological function: Functional assays revealed that circSETD3-plasmid inhibited cell proliferation, induced apoptosis, promoted caspase-3 activity, enhanced Bax and cleaved-Caspase 3 expression, and reduced Bcl-2 levels, and these effects were reversed by miR-421 mimic.
Molecular mechanism: BMF, a direct target of hsa-miR-421, was downregulated in CCA tissues and cell lines.
Survival: -
Supported No.:
 1
Description:

These findings demonstrate that circSETD3 inhibits proliferation and induces apoptosis in CCA cells by regulating the miR-421/BMF axis, indicating its potential as a promising candidate for CCA therapy.
Other information
Title:

CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression.

Journal: Bioengineered
Published: 2022/4/19
PubMed ID: 35435120