circRNA basic information
circBase ID: -
Name: hsa_circ_DLST
Synonym: circDLST
Host Gene: hsa-miR-489-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: GC cell lines (HGC-27, MKN-45)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-489-3p
Biological function: AS-IV restrained cell proliferation and metastasis in GC cells by downregulating circDLST.
Molecular mechanism: CircDLST served as a hsa-miR-489-3p sponge, and hsa-miR-489-3p inhibition reversed anti-tumor function of AS-IV. EIF4A1 was a target for hsa-miR-489-3p and circDLST sponged hsa-miR-489-3p to regulate EIF4A1.
Survival: -
Supported No.:
 2
Description:

AS-IV inhibited the development of GC through circDLST/miR-489-3p/EIF4A1 axis.
Other information
Title:

Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway.

Journal: Bioengineered
Published: 2022/4/19
PubMed ID: 35435117