circRNA basic information
circBase ID: hsa_circ_0065378
Name: hsa_circ_PLXNB1
Synonym: circ_PLXNB1
Host Gene: hsa-miR-4701-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human colorectal cells (FHC), colorectal cancer cell lines (HT29, SW480, HCT-116, SW620)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-4701-5p
Biological function: Overexpression of circ_PLXNB1 inhibited the malignant behaviors of CRC cells, as manifested by the decrease in cell proliferation, cell invasion, migration, and EMT.
Molecular mechanism: Mechanistically, circ_PLXNB1 exerted its functional effects by binding with hsa-miR-4701-5p. Moreover, TUSC1 siRNA partially abolished the suppressive effect of the hsa-miR-4701-5p inhibitor or circ_PLXNB1 on CRC cell malignant behaviors.
Survival: -
Supported No.:
 1
Description:

Circ_PLXNB1 attenuated CRC progression by binding with miR-4701-5p to overexpress TUSC1, indicating that the circ_PLXNB1/miR-4701-5p/TUSC1 axis might be a potential novel molecular target in CRC diagnosis and therapy.
Other information
Title:

Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression.

Journal: J Gastroenterol Hepatol
Published: 2022/4/19
PubMed ID: 35434854