circRNA basic information
circBase ID: -
Name: hsa_circ_TMEM59
Synonym: CircTMEM59
Host Gene: hsa-miR-410-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cells (SW480, SW620, LOVO, HCT116), normal colon epithelial cells (HCoEpiC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-410-3p
Biological function: Upregulation of circTMEM59 repressed CRC cell proliferation, migration and invasion.
Molecular mechanism: hsa-miR-410-3p could be sponged by circTMEM59, and its mimic also reversed the inhibition effect of circTMEM59 on CRC cell proliferation and metastasis. Also, HOXD8 was targeted by hsa-miR-410-3p, and its knockdown abolished the negative regulation of hsa-miR-410-3p inhibitor on CRC cell proliferation and metastasis.
Survival: -
Supported No.:
 2
Description:

In summary, our results demonstrated that circTMEM59 participated in the regulation of CRC progression through the miR-410-3p/HOXD8 axis, showing that circTMEM59 might be a potential target for the treatment of CRC.
Other information
Title:

CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8.

Journal: Biochem Genet
Published: 2022/4/16
PubMed ID: 35426617