circRNA basic information
circBase ID: -
Name: hsa_circ_FNDC3B
Synonym: circFNDC3B
Host Gene: hsa-miR-942, hsa-miR-510
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: MKN28 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-942, hsa-miR-510
Biological function: increase the migration and invasion of gastric cancer (GC) cells.
Molecular mechanism: CircFNDC3B was found to target hsa-miR-942 and hsa-miR-510 and suppress their expressions respectively. Moreover, hsa-miR-942 was found to target CD44 mRNA while hsa-miR-510 was found to target CDH1 mRNA. The overexpression of circFNDC3B led to the down-regulation of hsa-miR-942 and hsa-miR-510, which accordingly resulted in the up-regulation of CD44 and CDH1 in MKN28 cells.
Survival: -
Supported No.:
 4
Description:

In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. And the up-regulation of CD44 and CDH1 would accordingly result in a higher recurrence rate of EGC patients treated by ESD.
Other information
Title:

The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients.

Journal: Sci Rep
Published: 2022/4/15
PubMed ID: 35418175