circRNA basic information
circBase ID: hsa_circ_0050908
Name: -
Synonym: Circ_0050908
Host Gene: hsa-miR-324-5p
 
 
 
Disease basic information
DO ID:
 936
DO name: brain disease
Disease details: ischemia-reperfusion
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human-derived cardiomyocytes (HCMs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-324-5p
Biological function: I/R stimulation up-regulated circ_0050908 expression in cardiomyocytes. Functional experiments suggested that circ_0050908 knockdown led to the rescue of apoptosis enhancement, inflammation, and oxidative stress induced by I/R in cardiomyocytes.
Molecular mechanism: circ_0050908 directly targeted hsa-miR-324-5p, and hsa-miR-324-5p inhibition reversed the inhibitory action of circ_0050908 knockdown on myocardial I/R injury. TRAF3 was verified to be a target of hsa-miR-324-5p, and hsa-miR-324-5p suppressed I/R-induced apoptosis, inflammatory response, and oxidative stress in cardiomyocytes through TRAF3. Besides that, circ_0050908 could regulate TRAF3 expression by hsa-miR-324-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0050908 knockdown protects cardiomyocytes against I/R injury by reducing apoptosis, inflammatory response, and oxidative stress through miR-324-5p/TRAF3 axis, revealing a novel therapeutic strategy for preventing myocardial I/R injury.
Other information
Title:

Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.

Journal: Int Immunopharmacol
Published: 2022/4/13
PubMed ID: 35413678