circRNA basic information
circBase ID: hsa_circ_0001946
Name: -
Synonym: circ_0001946
Host Gene: hsa-miR-1290
 
 
 
Disease basic information
DO ID:
 1107
DO name: esophageal carcinoma
Disease details: esophageal squamous cell cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: ESCC cell lines (ECA109, KYSE450)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOX6
Associated microRNA: hsa-miR-1290
Biological function: Circ_0001946 expression was attenuated in human ESCC, and circ_0001946 increase impeded cell proliferation, invasion, migration and enhanced apoptosis in vitro. Moreover, circ_0001946 increase diminished xenograft growth in vivo.
Molecular mechanism: circ_0001946 bound to hsa-miR-1290, and re-expression of hsa-miR-1290 reversed circ_0001946-dependent cell properties. SOX6 was a hsa-miR-1290 target and it was responsible for the regulation of hsa-miR-1290 in cell properties. Furthermore, circ_0001946 functioned as a ceRNA to regulate SOX6 expression via hsa-miR-1290.
Survival: -
Supported No.:
 1
Description:

Our findings uncover an undescribed molecular mechanism, the circ_0001946/miR-1290/SOX6 ceRNA crosstalk, for the anti-ESCC activity of circ_0001946.
Other information
Title:

Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer.

Journal: Thorac Cancer
Published: 2022/4/13
PubMed ID: 35411716