circRNA basic information
circBase ID: hsa_circ_0026646
Name: -
Synonym: hsa_circ_0026646
Host Gene: -
 
 
 
Disease basic information
DO ID:
 319
DO name: spinal cord disease
Disease details: spinal cord injury
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: tPLXNB2and hsa_circ_0026646 were upregulated in SCI, whereas miR-331-3p was downregulated, and, interestingly, similar expression profiles were confirmed using the rat SCI model.
Molecular mechanism: fluorescent reporter assay indicated that both hsa_circ_0026646 andPLXNB2have hsa-miR-331-3p target sites, and the ceRNA hypothesis suggested the dysregulation of hsa_circ_0026646, hsa-miR-331-3p, andPLXNB2in SCI.
Survival: -
Supported No.:
 1
Description:

in SCI pathogenesis, hsa_circ_0026646 correlates withPLXNB2by targeting miR-331-3p.
Other information
Title:

Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis.

Journal: Exp Biol Med (Maywood)
Published: 2022/4/13
PubMed ID: 35410505