circRNA basic information
circBase ID: hsa_circ_0007331
Name: -
Synonym: circ_0007331
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCT 8 as well as SW620 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: high-mobility
Associated microRNA: hsa-miR-205-5p
Biological function: circ_0007331 is expressed more frequently in patients with CRC. The inhibition of circ_0007331 expression reduced the viability, colony formation, migration, and invasion of CRC cells.
Molecular mechanism: Inhibition of hsa-miR-205-5p or elevation of high-mobility group A2 (HMGA2) can reverse the function of inhibited circ_0007331 in tumor cells.
Survival: -
Supported No.:
 1
Description:

the circ_0007331/miR-205-5p/HMGA2 axis promotes CRC development. Thus, circ_0007331 may be a potential biomarker for CRC.
Other information
Title:

Circle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis.

Journal: Bioengineered
Published: 2022/4/12
PubMed ID: 35400282