circRNA basic information
circBase ID: hsa_circ_0001141
Name: hsa_circ_ITCH
Synonym: CircITCH
Host Gene: hsa-miR-184
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human normal liver cell lines (LO2), HCC cell lines (Huh7, HCCLM3, SMMC-7721, MHCC97H, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-184
Biological function: CircITCH (hsa_circ_0001141) was a stable circRNA and downregulated in HCC cells. Overexpression of circITCH inhibited cell proliferation, migration, invasion, and promoted apoptosis in vitro and in vivo, whereas knockdown of circITCH had the opposite effects.
Molecular mechanism: hsa-miR-184 could be sponged by circITCH, and its overexpression could mitigate the suppressive effects of circITCH overexpression on HCC progression. Through biological website to predict the target genes of hsa-miR-184 may be combined. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to investigate mRNAs with significant functional enrichment and pathways, also which its relationship with HCC-related pathway and immune cells.
Survival: -
Supported No.:
 5
Description:

circITCH served as a repressor to restrain HCC malignancy via miR-184. Therefore, circITCH may serve as a potential prognostic marker and therapeutic target for HCC.
Other information
Title:

Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184.

Journal: Cell Cycle
Published: 2022/4/12
PubMed ID: 35400275