circRNA basic information
circBase ID: hsa_circ_0003528
Name: hsa_circ_SEC24A
Synonym: CircSEC24A
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: HCC cell lines (HCCLM3, Hep3B), normal hepatocytes (THLE-2)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: MMP3
Associated microRNA: hsa-miR-421
Biological function: A xenograft model was used to evaluate the role of circSEC24Ain vivo. circSEC24A expression was significantly upregulated in HCCLM3 and Hep3B cells. Silencing circSEC24A mitigated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, which was abrogated by downregulation of miR-421.
Molecular mechanism: MMP3 could bind to hsa-miR-421 to decrease the functional effects of hsa-miR-421 and induce tumor metastasis. Knockdown of cicSEC24A suppressed tumor growthin vivo. circSEC24A interference suppressed HCC cell EMT by sponging hsa-miR-421, further regulating MMP3, and inhibiting tumor growthin vivo.
Survival: -
Supported No.:
 4
Description:

circSEC24A could represent a potential target for HCC patient treatment.
Other information
Title:

CircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis.

Journal: Bioengineered
Published: 2022/4/12
PubMed ID: 35400271