circRNA basic information
circBase ID: -
Name: hsa_circ_FAM126A
Synonym: circFAM126A
Host Gene: hsa-miR-613
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: normal human lung epithelial cell line (BEAS-2B cells), NSCLC cell line (A549 cells,PC9 cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-613
Biological function: CircFAM126A was obviously overexpressed in NSCLC tissues and cells when compared with controls. The loss-of-functional experiments suggested that knockdown of circFAM126A suppressed proliferation, migration and invasion, as well as caused apoptosis and cell cycle arrest in NSCLC cells, which was abolished by silencing of miR-613.
Molecular mechanism: IRS2 was a target gene of hsa-miR-613. Overexpression of hsa-miR-613 exerted carcinoma inhibitor role in NSCLC by inhibition of IRS2 expression. Consistently, the silencing of circFAM126A also functioned anti-tumorigenic roles in nude mice in vivo.
Survival: -
Supported No.:
 1
Description:

circFAM126A could function as a miRNA sponge for miR-613 to regulate the expression of IRS2, thereby regulating proliferation, migration, invasion, apoptosis, and cell cycle arrest in NSCLC cells.
Other information
Title:

CirRNA circFAM126A Exerts Oncogenic Functions in NSCLC to Upregulate IRS2.

Journal: Biochem Genet
Published: 2022/4/10
PubMed ID: 35397054