circRNA basic information
circBase ID: -
Name: hsa_circ_DNER
Synonym: circDNER
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung cancer cell lines (BEAS_2B, HCC827, A549, H1975, H1299, H460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ITGB8.
Associated microRNA: hsa-miR-139-5p
Biological function: Inhibition of circDNER reduced IC50 of PTX, inhibited cell proliferation, invasion and migration, as well as promoted cell apoptosis in PTX-resistant lung cancer cells.
Molecular mechanism: circDNER sponged hsa-miR-139-5p to upregulate ITGB8 expression. Overexpression of hsa-miR-139-5p reversed the biological functions mediated by circDNER in PTX-resistant lung cancer cells. hsa-miR-139-5p overexpression suppressed PTX resistance and malignant behaviors of PTX-resistant lung cancer cells, with ITGB8 elevation rescued the impacts. Moreover, we demonstrated that circDNER was upregulated in plasma exosomes from lung cancer patients. The plasma exosomes derived from these patients are the key factors enhancing the migration and invasion potential of lung cancer cells.
Survival: -
Supported No.:
 1
Description:

The circDNER mediated miR-139-5p/ITGB8 axis suppresses lung cancer progression. Our findings suggest that circDNER might act as a potential prognostic biomarker and therapeutic target for lung cancer treatment.
Other information
Title:

Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8.

Journal: Thorac Cancer
Published: 2022/4/10
PubMed ID: 35396925