circRNA basic information
circBase ID: -
Name: hsa_circ_GSE1
Synonym: circGSE1
Host Gene: hsa-miR-324-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: HCC cell lines (HepG2, Huh7, PLC, HCCLM3, SMMC_7721, Hep3B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-324-5p
Biological function: In vivo animal metastasis models and bioluminescence imaging were used to verify the effect of exosomal circGSE1 on tumor progression.
Molecular mechanism: exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes the progression of HCC by inducing Tregs expansion via regulating the hsa-miR-324-5p/TGFBR1/Smad3 axis.
Survival: -
Supported No.:
 1
Description:

exosomal circGSE1 can be used as a promising biomarker for immunotherapy of HCC.
Other information
Title:

Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells.

Journal: Cancer Sci
Published: 2022/4/10
PubMed ID: 35396771