circRNA basic information
circBase ID: hsa_circ_0011298
Name: hsa_circ_TINAGL1
Synonym: -
Host Gene: hsa-miR-486-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: NSCLC cells (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CRABP2
Associated microRNA: hsa-miR-486-3p
Biological function: Circ_0011298 was overexpressed in Taxol-resistant NSCLC cells and tissues. Circ_0011298 knockdown enhanced Taxol sensitivity by decreasing cell proliferation, migration, invasion, and glycolysis and inducing apoptosis and cell cycle arrest in Taxol-resistant NSCLC cells.
Molecular mechanism: Circ_0011298 was a sponge of hsa-miR-486-3p, and the impact of circ_0011298 silencing on Taxol resistance was rescued by hsa-miR-486-3p inhibition. Moreover, hsa-miR-486-3p directly targeted CRABP2, and hsa-miR-486-3p inhibited Taxol resistance by targeting CRABP2. Furthermore, circ_0011298 regulated CRABP2 expression through targeting hsa-miR-486-3p. Importantly, circ_0011298 interference elevated Taxol sensitivity of NSCLC in vivo.
Survival: -
Supported No.:
 2
Description:

Circ_0011298 elevated Taxol resistance of NSCLC by sponging miR-486-3p and upregulating CRABP2, providing a possible circRNA-targeted therapy for NSCLC.
Other information
Title:

Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis.

Journal: J Clin Lab Anal
Published: 2022/4/10
PubMed ID: 35396749