circRNA basic information
circBase ID: hsa_circ_0075825
Name: -
Synonym: Circ_0075825
Host Gene: hsa-miR-432-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (AGS, NUGC4, MKN74, BGC-803), normal human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-432-5p
Biological function: Circ_0075825 expression was raised in GC tissues and cell lines. Circ_0075825 overexpression promoted the proliferative, migrative and invasive abilities of GC cells, while inhibiting apoptosis, while depletion of circ_0075825 suppressed the malignant biological behaviors of GC cells.
Molecular mechanism: SOX9 was identified as one of the direct target genes of hsa-miR-432-5p, and circ_0075825 repressed the expression of hsa-miR-432-5p, to induce the expression of SOX9. Furthermore, hsa-miR-432-5p overexpression counteracted the promoting effect of circ_0075825 on the malignancy of GC cells.
Survival: -
Supported No.:
 1
Description:

Circ_0075825 promotes GC progression via sponging miR-432-5p to regulate SOX9 expression level, and it may be a novel therapeutic target for treating GC.
Other information
Title:

Circ_0075825 promotes gastric cancer progression via adsorbing miR-432-5p to modulate SOX9.

Journal: Clinics (Sao Paulo)
Published: 2022/4/9
PubMed ID: 35395444