circRNA basic information
circBase ID: hsa_circ_0008344
Name: hsa_circ_UBAP2
Synonym: circ_0008344
Host Gene: hsa-miR-638
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma tumor
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human astrocytes (NHA), astrocytoma U251 , glioblastomas T98G, A172
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SZRD1
Associated microRNA: hsa-miR-638
Biological function: Abundances of circ_0008344 and SUZ RNA binding domain containing 1 (SZRD1) were highly elevated, while miR-638 was downregulated in glioma tumors and cells. Circ_0008344 was identified as a stable circRNA with a circular structure. Silencing circ_0008344 could restrain glioma proliferation, migration, invasion, and angiogenesis.
Molecular mechanism: Circ_0008344 functioned as a sponge for hsa-miR-638. The negative regulation of circ_0008344 knockdown on glioma progression and angiogenesis could be reversed by hsa-miR-638 inhibitor. SZRD1 was a target of hsa-miR-318, and its overexpression overturned the inhibition effect of hsa-miR-638 mimic on glioma progression and angiogenesis. Meanwhile, we confirmed that circ_0008344 knockdown inhibited SZRD1 expression, and its effect was reversed by hsa-miR-638 inhibitor.
Survival: -
Supported No.:
 1
Description:

circ_00008344 knockdown suppressed glioma tumor growth. Circ_0008344 might contribute to glioma progression through miR-638/SZRD1 axis, which might be a novel pathology and treatment target in glioma.
Other information
Title:

Hsa_circ_0008344 Promotes Glioma Tumor Progression and Angiogenesis Presumably by Regulating miR-638/SZRD1 Pathway.

Journal: Neurotox Res
Published: 2022/4/9
PubMed ID: 35394558