circRNA basic information
circBase ID: -
Name: hsa_circ_MYBL2
Synonym: circ-MYBL2
Host Gene: hsa-miR-19a
 
 
 
Disease basic information
DO ID:
 4074
DO name: pancreatic adenocarcinoma
Disease details: pancreatic adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PA cells SW1990, PANC-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-19a
Biological function: Downregulation of circ-MYBL2 and upregulation of miR-19a were observed in PA.
Molecular mechanism: In PA cells, circ-MYBL2 decreased the accumulation of hsa-miR-19a but increased its RNA gene methylation. Overexpression of circ-MYBL2 decreased PA cell proliferation and movement, while overexpression of hsa-miR-19a showed an opposite effect. In addition, circ-MYBL2 suppressed the role of hsa-miR-19a in cell proliferation, migration, and invasion.
Survival: -
Supported No.:
 1
Description:

circ-MYBL2 was downregulated in PA and it downregulated miR-19a through methylation to suppress PA cell proliferation.
Other information
Title:

MM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells.

Journal: Bioengineered
Published: 2022/4/8
PubMed ID: 35387554