circRNA basic information
circBase ID: hsa_circ_0006014
Name: hsa_circ_ILKAP
Synonym: circ_0006014
Host Gene: hsa-miR-885-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Breast cancer cell lines (MDA-MB-231, MCF-7), human embryonic kidney cell line (293 T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-885-3p
Biological function: higher expression of hsa_circ_0006014 in breast tumor samples than in matched adjacent normal samples, and its expression was positively correlated with histological grade (grade iii). Phenotypically, hsa_circ_0006014 promoted the proliferation of MDA-MB-231 and MCF-7 breast cancer cells.
Molecular mechanism: hsa_circ_0006014 and hsa-miR-885-3p, and hsa_circ_0006014 promoted breast cancer cell proliferation partially by sponging hsa-miR-885-3p and influenced CDK2/CCNE1 and CDK4/6/CCND1.
Survival: -
Supported No.:
 1
Description:

hsa_circ_0006014 promotes breast cancer progression by sponging miR-885-3p to regulate the NTRK2/PIK3CA/AKT axis.
Other information
Title:

Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway.

Journal: Aging (Albany NY)
Published: 2022/4/7
PubMed ID: 35383130