circRNA basic information
circBase ID: hsa_circ_0030042
Name: hsa_circ_FOXO1
Synonym: circ_0030042
Host Gene: hsa-miR-514a-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXO1
Associated microRNA: hsa-miR-514a-3p
Biological function: a novel circRNA hsa_circ_0030042, which is derived from its host gene forkhead box O1 (FOXO1), was upregulated in TNF-alpha-induced VSMCs.
Molecular mechanism: Silencing of hsa_circ_0030042 inhibited proliferation and migration while promoting apoptosis in TNF-alpha-induced VSMCs. Mechanically, hsa_circ_0030042 positively regulated FOXO1 expression via sponging hsa-miR-514a-3p.
Survival: -
Supported No.:
 2
Description:

Our study stated the vital role of the hsa_circ_0030042/miR-514a-3p/FOXO1 axis and provides a profound understanding about the circRNA in AS.
Other information
Title:

Hsa_circ_0030042 Facilitates the Proliferation and Migration of Vascular Smooth Muscle Cells via the miR-514a-3p/FOXO1 Axis.

Journal: J Endovasc Ther
Published: 2022/4/7
PubMed ID: 35382622