circRNA basic information
circBase ID: hsa_circ_0060927
Name: hsa_circ_CYP24A1
Synonym: circ_0060927
Host Gene: hsa-miR-421
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: BNCC provided human CRC cell lines (HCT116, SW480), human colorectal mucous membrane cell line (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: miR-195-5p.
Associated microRNA: hsa-miR-421
Biological function: Hsa_circ_0060927 expression was significantly upregulated, whereas miR-421 and miR-195-5p were downregulated in CRC tissues and cells compared with control groups. Hsa_circ_0060927 expression was closely associated with lymph node metastasis and tumor-node-metastasis stage. Caudatin treatment significantly decreased hsa_circ_0060927 expression but increased miR-421 and miR-195-5p expression. Caudatin exposure suppressed CRC cell proliferation, migration and invasion, and induced cell apoptosis
Molecular mechanism: hsa_circ_0060927 overexpression hindered these impacts. Additionally, hsa_circ_0060927 was associated with hsa-miR-421/hsa-miR-195-5p. Depletion of hsa-miR-421 or hsa-miR-195-5p attenuated the influences of hsa_circ_0060927 silencing on CRC development. Furthermore, Caudatin treatment repressed tumor growth in vivo.
Survival: -
Supported No.:
 2
Description:

Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR-195-5p pathway, which provided a potential therapeutic agent for CRC.
Other information
Title:

Hsa_circ_0060927 participates in the regulation of Caudatin on colorectal cancer malignant progression by sponging miR-421/miR-195-5p.

Journal: J Clin Lab Anal
Published: 2022/4/5
PubMed ID: 35373390