circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circ_LARP4
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: MCF-7 breast cancer cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Compared with the control group, circ_LARP4 overexpression group showed an upregulation in the expression of circ_LARP4, decreased cell proliferation, and down-regulated expression of ki67.
Molecular mechanism: It also reported the up-regulated expression of p21, smaller tumor stem cell bullet size, and decreased the expression of OCT4 and SOX2, together with the decreased number of invaded cells, decreased expression of VEGF and N-cadherin, increased expression of E-cadherin, and decreased levels of iNOS and IL-1beta.
Survival: -
Supported No.:
 2
Description:

Overexpression of circ_LARP4 inhibits the proliferation, invasion and stem cell-like characteristics of MCF-7 breast cancer cells, and down-regulates the levels of iNOS and IL-1beta.
Other information
Title:

[Overexpression of circ_LARP4 inhibits the proliferation and migration of MCF-7 human breast cancer cells and its mechanism].

Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Published: 2022/4/3
PubMed ID: 35365990