circRNA basic information
circBase ID: hsa_circ_0047921
Name: -
Synonym: Circ_0047921
Host Gene: hsa-miR-1287-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human bronchiolar epithelial cell line (BEAS-2B), lung cancer cell lines (A549, H1299, H1650, Calu3, SK-MES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1287-5p
Biological function: Circ_0047921 was highly expressed in lung cancer tissues and cells. Circ_0047921 downregulation repressed proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) and glycolysis in lung cancer cells.
Molecular mechanism: Circ_0047921 targeted hsa-miR-1287-5p to deplete hsa-miR-1287-5p expression. The effects caused by circ_0047921 downregulation were reversed by hsa-miR-1287-5p inhibition. In addition, LARP1 was a target of hsa-miR-1287-5p, and circ_0047921 could directly interact with hsa-miR-1287-5p to increase the expression of LARP1. The effects caused by circ_0047921 downregulation were also reversed by LARP1 overexpression. Circ_0047921 silencing impeded the growth of tumor in vivo.
Survival: -
Supported No.:
 1
Description:

Circ_0047921 was overexpressed in lung cancer, and circ_0047921 targeted miR-1287-5p to modulate LARP1 expression, thereby facilitating the development of lung cancer.
Other information
Title:

Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells.

Journal: World J Surg Oncol
Published: 2022/4/3
PubMed ID: 35365169