circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: circ-TLK1
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (HepG2, SK-hep1, HCCLM3, Huh7), normal fetal hepatocyte cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-138-5p
Biological function: circ-TLK1 was highly expressed in HCC samples, and its high expression was closely associated with poor clinicopathological variables of HCC patients.
Molecular mechanism: Knockdown of circ-TLK1 remarkably inhibited the proliferation, migration, invasion, and EMT of HCC cells, while circ-TLK1 overexpression promoted these malignant behaviors. Moreover, we noted that circ-TLK1 was capable of binding to hsa-miR-138-5p and upregulating its target gene, SOX4 in HCC. Based on rescue assays, hsa-miR-138-5p inhibition partially suppressed the effects of circ-TLK1 knockdown on the malignant behaviors of HCC cells.
Survival: -
Supported No.:
 1
Description:

circ-TLK1 functions as an oncogene in HCC progression partly through acting as a ceRNA of miR-138-5p, which may be a promising target for HCC therapy.
Other information
Title:

Circular RNA TLK1 Exerts Oncogenic Functions in Hepatocellular Carcinoma by Acting as a ceRNA of miR-138-5p.

Journal: J Oncol
Published: 2022/4/2
PubMed ID: 35359342