circRNA basic information
circBase ID: -
Name: -
Synonym: circ 001372
Host Gene: hsa-miR-128-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: ovalbumin-induced asthma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: A549 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-128-3p
Biological function: In the vivo model of asthma, the serum of circ 001372 was reduced. Down-regulation of circ 001372 increased inflammation reaction (TNF-alpha, IL-1beta, IL-6, and IL-18) and induced COX-2 and iNOS protein expression in vitro model through activation of NFAT5 and suppression of Sirt1.
Molecular mechanism: Up-regulation of circ 001372 decreased inflammation reaction (TNF-alpha, IL-1beta, IL-6, and IL-18) in vitro model through inactivation of NFAT5 and induction of Sirt1 by miRNA-128-3p. The miRNA-128-3p lowered the effects of circ 001372 on inflammation in vitro model. The Sirt1 inhibitor reduced the effects of circ 001372 on inflammation in vitro model.
Survival: -
Supported No.:
 1
Description:

the serum of circ 001372 against inflammation in ovalbumin-induced asthma through Sirt1/NFAT5 by miRNA-128-3p.
Other information
Title:

Circular RNA has Circ 001372-Reduced Inflammation in Ovalbumin-Induced Asthma Through Sirt1/NFAT5 Signaling Pathway by miRNA-128-3p.

Journal: Mol Biotechnol
Published: 2022/3/31
PubMed ID: 35353360