circRNA basic information
circBase ID: -
Name: hsa_circ_BACH1
Synonym: circBACH1
Host Gene: hsa-miR-200a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatoma
Species: human
Species details: human
Sample type: cell line
Sample type details: Hepatoma cell lines (HepG2, Huh7), 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAP3K2
Associated microRNA: hsa-miR-200a-3p
Biological function: Expression of circBACH1 and MAP3K2 was increased, while miR-200a-3p expression was decreased in HCC tissues and HBV-transfected hepatoma cells. Depletion of circBACH1 or miR-200a-3p overexpression impeded HBV replication, proliferation, and metastasis in HBV-transfected hepatoma cells.
Molecular mechanism: CircBACH1 was able to regulate MAP3K2 expression by sponging hsa-miR-200a-3p. CircBACH1 regulated HBV replication and hepatoma progression through the hsa-miR-200a-3p/MAP3K2 pathway. Moreover, circBACH1 deficiency hampered tumor growth in vivo.
Survival: -
Supported No.:
 3
Description:

CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis.
Other information
Title:

CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis.

Journal: Histol Histopathol
Published: 2022/3/31
PubMed ID: 35352818