circRNA basic information
circBase ID: -
Name: hsa_circ_WSB1
Synonym: circWSB1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: human BC cell lines (MDA-MB-231, MCF-7, SKBR-3, MDA-MB-453, BT-549), normal mammary epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: the expression of circWSB1 was significantly upregulated in BC tissues and correlated with poor clinical outcomes, which might serve as an independent prognostic factor for BC patients. Ectopic expression of circWSB1 promoted the proliferation of BC cell in vitro and in vivo.
Molecular mechanism: circWSB1 was transcriptionally upregulated by HIF1alpha in response to hypoxia and could competitively bind to deubiquitinase USP10 to prevent the access of p53 to USP10 in BC cells, leading to degradation of p53 and tumor progression of BC.
Survival: poor
Supported No.:
 1
Description:

disclose a novel mechanism that hypoxia-inducible circWSB1 could interact with USP10 to attenuate USP10 mediated p53 stabilization and promote the progression of BC, providing an alternative prognostic biomarker and therapeutic target for BC.
Other information
Title:

Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10.

Journal: Mol Cancer
Published: 2022/3/31
PubMed ID: 35351136