circRNA basic information
circBase ID: hsa_circ_0001017
Name: hsa_circ_XPO1
Synonym: circ_0001017
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: cell line
Sample type details: human OS cell lines (Saos-2, U2OS, MG63), osteoblast cell lines (HECC, hFOB1.19, HFF-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-145-5p
Biological function: A total of 241 CDECs, including 75 upregulated and 166 downregulated CDECs, were identified in three OS cell lines compared with normal vascular endothelial cells. PCR validation showed that hsa_circ_0000704, hsa_circ_0001017 and hsa_circ_0005035 were all highly expression in the three OS cell lines, compared with osteoblast cell lines (HECC, hFOB1.19 and HFF-1).
Molecular mechanism: overexpression of circ_0001017 significantly promoted the cell proliferation, migration and invasion and decreased apoptosis in U2OS cells. Knockdown of circ_0001017 obtained the opposite results. Circ_0001017 may downregulate hsa-miR-145-5p through direct binding. Furthermore, the expression of hsa-miR-145-5p was negatively regulated by circ_0001017 in OS cells. In addition, further functional studies indicated that hsa-miR-145-5p inhibitor eliminated the effects caused by si-circ_0001017 in OS cells.
Survival: -
Supported No.:
 2
Description:

In conclusion, our study suggested that circ_0001017 may be a novel oncogenic factor during the progression and development of OS by targeting miR-145-5p.
Other information
Title:

Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p.

Journal: J Orthop Surg Res
Published: 2022/3/30
PubMed ID: 35346268