circRNA basic information
circBase ID: -
Name: hsa_circ_DHDDS
Synonym: circDHDDS
Host Gene: hsa-miR-362-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: TNBC cell lines (MDA-MB-231, MDA-MB-468)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX5
Associated microRNA: hsa-miR-362-3p
Biological function: The contents of circDHDDS and DDX5 were increased, and miR-362-3p level was decreased in TNBC. CircDHDDS deficiency reserved cell proliferation, migration, invasion and angiogenesis, while facilitated cell apoptosis in TNBC cells. Furthermore, miR-362-3p was validated to exert a tumor repressive effect in TNBC cells by suppressing DDX5. Moreover, DDX5 could regulate the development of TNBC.
Molecular mechanism: The experimental data exposed that levels of hsa-miR-362-3p presented noteworthy negative correlation with circDHDDS and DDX5, while circDHDDS and DDX5 exhibited significant positive correlation. In mechanism, circDHDDS bound to hsa-miR-362-3p to modulate DDX5 expression. In addition, circDHDDS knock-down also attenuated tumor growth.
Survival: -
Supported No.:
 1
Description:

CircDHDDS expedited TNBC by swelling DDX5 via adapting miR-362-3p.
Other information
Title:

Circular RNA dehydrodolichyl diphosphate synthase facilitated triple-negative breast cancer progression via miR-362-3p/DDX5 axis.

Journal: Environ Toxicol
Published: 2022/3/29
PubMed ID: 35343646