circRNA basic information
circBase ID: hsa_circ_0078767
Name: -
Synonym: Circ_0078767
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial cells (BEAS-2B), lung cancer cell line (A549, HCC827 H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-665
Biological function: The expression of circ_0078767 and GPX3 was decreased in NSCLC tissues, while the expression of miR-665 was increased. Circ_0078767 can sponge miR-665, and GPX3 is the target of miR-665. In vitro complement experiments showed that knockdown of circ_0078767 significantly promoted malignant behavior of NSCLC, while cotransfection of miR-665 inhibitor partially reduced this change. In addition, the GPX3 overexpression decreased the promoting effects of miR-665 upregulation on proliferation, migration, and invasion of NSCLC cells.
Molecular mechanism: circ_0078767 regulates the GPX3 expression in NSCLC cells by spongy hsa-miR-665. In addition, in vivo studies have shown that downregulation of circ_0078767 promotes tumor growth.
Survival: -
Supported No.:
 1
Description:

Circ_0078767 silencing promotes proliferation, migration, invasion, and glycolysis of NSCLC cells by regulating the miR-665/GPX3 axis, suggesting that circ_0078767/miR-665/GPX3 axis may be a potential regulatory mechanism for the treatment of NSCLC.
Other information
Title:

Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665.

Journal: Int J Genomics
Published: 2022/3/29
PubMed ID: 35340708