circRNA basic information
circBase ID: hsa_circ_0086720
Name: hsa_circ_UBAP2
Synonym: circ_0086720
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: gastric cancer cell lines (AGS, BGC_823, HGC_27, MGC_803), normal gastric epithelial cell line (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Hsa_circ_0086720 was found to be downregulated in gastric carcinogenesis, and tissue hsa_circ_0086720 was negatively associated with perineural invasion, Borrmann type, disease-free survival, and overall survival. Hsa_circ_0086720 was stable in circulating plasma and was actively secreted by cells in gastric carcinogenesis.
Molecular mechanism: As a biomarker for early GC screening, plasma hsa_circ_0086720 had good sensitivity and specificity, and its stability met the clinical application requirements. Bioinformatics analysis suggested that dysregulated hsa_circ_0086720 has important functions in gastric carcinogenesis. Univariate Cox regression analysis identified factors associated with overall survival time and disease-free survival time. The nomograms showed good accuracy of predicting survival time.
Survival: poor
Supported No.:
 2
Description:

Hsa_circ_0086720 is a novel biomarker for screening early GC and predicting the prognosis of advanced-stage patients.
Other information
Title:

Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application.

Journal: J Clin Lab Anal
Published: 2022/3/26
PubMed ID: 35334500