circRNA basic information
circBase ID: -
Name: hsa_circ_SAR1A
Synonym: Circ_SAR1A
Host Gene: hsa-miR-21-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung cancer cell lines (H1650, H1581, H460, H1299, A549), normal human bronchial epithelial cells (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TXNIP
Associated microRNA: hsa-miR-21-5p
Biological function: circ_SAR1A and TXNIP were down-regulated while miR-21-5p was up-regulated in lung cancer samples and cells.
Molecular mechanism: circ_SAR1A was located predominantly in the cytoplasm, it inhibited lung cancer growth in vitro and in vivo by sponging to hsa-miR-21-5p. hsa-miR-21-5p silencing suppressed lung cancer malignancy by targeting TXNIP.
Survival: -
Supported No.:
 1
Description:

circ_SAR1A is a critical negative regulator of lung carcinogenesis. circ_SAR1A/miR-21-5p/TXNIP attenuation inhibited lung cancer progression, presenting an ideal diagnostic and a potential therapeutic target.
Other information
Title:

Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR-21-5p/TXNIP axis.

Journal: J Clin Lab Anal
Published: 2022/3/26
PubMed ID: 35334496