circRNA basic information
circBase ID: -
Name: hsa_circ_ADAMTS6
Synonym: circADAMTS6
Host Gene: hsa-miR-324-5p
 
 
 
Disease basic information
DO ID:
8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCs cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PIK3R3
Associated microRNA: hsa-miR-324-5p
Biological function: Abundances of circADAMTS6 and phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) were underexpressed, and microRNA (miR)-324-5p was elevated in human osteoarthritic tissues and IL-1beta-induced HCs. Overexpressing circADAMTS6 and inhibiting miR-324-5p enhanced proliferation and ECM synthesis, but suppressed apoptosis and inflammatory response in IL-1beta-challenged HCs. Besides, silencing circADAMTS6 caused similar effects of IL-1beta stress on HCs.
Molecular mechanism: there was a direct interaction between hsa-miR-324-5p and circADAMTS6 or PIK3R3, and IL-1beta-induced activation of PI3K/AKT/mTOR signaling pathway was suppressed by circADAMTS6 overexpression and hsa-miR-324-5p silencing. Furthermore, counteractive effects of hsa-miR-324-5p upregulation on circADAMTS6 overexpression and PIK3R3 knockdown on hsa-miR-324-5p silencing were observed.
Survival: -
Supported No.:
2
Description:

CircADAMTS6-miR-324-5p-PIK3R3 axis might participate in IL-1beta-induced HCs dysfunction via competing endogenous RNA mechanism and the PI3K/AKT/mTOR signaling pathway.

Other information
Title:

Regulation of circADAMTS6-miR-324-5p-PIK3R3 ceRNA pathway may be a novel mechanism of IL-1beta-induced osteoarthritic chondrocytes.

Journal: J Bone Miner Metab
Published: 2022/3/26
PubMed ID: 35333985