circRNA basic information
circBase ID: hsa_circ_0055412
Name: -
Synonym: circ_0055412
Host Gene: -
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: Glioma cells (H4, A172, U251, LN229), normal human glial cell line (HEB), HEK_293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Circ_0055412 was found to be notably upregulated in glioma cells. Moreover, depletion of circ_0055412 enhanced cisplatin sensitivity of glioma cells in vitro and in vivo.
Molecular mechanism: circ_0055412 recruited eukaryotic translation initiation factor 4A3 (EIF4A3) protein to stabilize capping actin protein, gelsolin like (CAPG) mRNA. Furthermore, circ_0055412 served as a sponge for microRNA-330-3p (hsa-miR-330-3p) and regulated nuclear factor of activated T cells 3 (NFATC3) expression to activate the transcription of catenin beta 1 (CTNNB1), thus participating in the activation of Wnt/beta-catenin signaling pathway.
Survival: -
Supported No.:
 1
Description:

Circ_0055412 contributed to cisplatin resistance of glioma cells via stabilizing CAPG mRNA and modulating Wnt/beta-catenin signaling pathway. This finding might provide novel information for the treatment of glioma.
Other information
Title:

Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/beta-catenin signaling pathway.

Journal: CNS Neurosci Ther
Published: 2022/3/26
PubMed ID: 35332692