circRNA basic information
circBase ID: hsa_circ_0043947
Name: -
Synonym: Circ_0043947
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: cell line
Sample type details: human primary chondrocytes (isolated from healthy subjects)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-671-5p
Biological function: Interleukin 1beta (IL-1beta) stimulation up-regulated the expression of circ_0043947 in chondrocytes. IL-1beta treatment restrained the viability and proliferation and induced the apoptosis, extracellular matrix degradation and inflammatory response of chondrocytes partly by up-regulating circ_0043947.
Molecular mechanism: Circ_0043947 interacted with hsa-miR-671-5p, and hsa-miR-671-5p silencing largely reversed circ_0043947 knockdown-mediated protective effects in IL-1beta-induced chondrocytes. hsa-miR-671-5p interacted with the 3 untranslated region (3UTR) of RTN3. hsa-miR-671-5p overexpression attenuated IL-1beta-induced injury in chondrocytes, and these protective effects were largely overturned by the overexpression of RTN3. Circ_0043947 acted as a molecular sponge for hsa-miR-671-5p to up-regulate RTN3 level in chondrocytes.
Survival: -
Supported No.:
 1
Description:

Circ_0043947 silencing alleviated IL-1beta-induced injury in chondrocytes by targeting miR-671-5p/RTN3 axis.
Other information
Title:

Circ_0043947 contributes to interleukin 1beta-induced injury in chondrocytes by sponging miR-671-5p to up-regulate RTN3 expression in osteoarthritis pathology.

Journal: J Orthop Surg Res
Published: 2022/3/26
PubMed ID: 35331286