circRNA basic information
circBase ID: hsa_circ_0058063
Name: -
Synonym: Circ_0058063
Host Gene: hsa-miR-330-3p
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: TC cell stains (KTC-1, TPC-1, SW579 cells), normal human thyroid cell stain (NTHY-ORI 3-1 cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SDC4
Associated microRNA: hsa-miR-330-3p
Biological function: Circ_0058063 was upregulated in TC tissues and cells, but miR-330-3p expression showed an opposite trend.
Molecular mechanism: Both silencing circ_0058063 and upregulating hsa-miR-330-3p can suppress the proliferation and migration of TC cells, upregulate Bax, and downregulate Bcl-2. In addition, circ_0058063 is able to target hsa-miR-330-3p that is also able to target syndecan 4 (SDC4).
Survival: -
Supported No.:
 1
Description:

circ_0058063 can act as a carcinogen in cases with TC via the miR-330-3p/SDC4 axis.
Other information
Title:

Circ_0058063 promotes progression of thyroid cancer by sponging miR-330-3p/SDC4 axis.

Journal: Anticancer Drugs
Published: 2022/3/25
PubMed ID: 35324533