circRNA basic information
circBase ID: hsa_circ_0070934
Name: hsa_circ_LARP1B
Synonym: circLMO1
Host Gene: hsa-miR-4291
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-4291
Biological function: The level of circLMO1 was down-regulated in cervical cancer tissues and was associated with the International Federation of Gynecology and Obstetrics (FIGO) staging. Functionally, circLMO1 overexpression inhibited cervical cancer growth and metastasis bothin vitroandin vivo, whereas circLMO1 depletion promoted cervical cancer cell proliferation and invasion.
Molecular mechanism: circLMO1 acted as a competing endogenous RNA (ceRNA) by sponging hsa-miR-4192 to repress target geneACSL4. CircLMO1 promoted cervical cancer cell ferroptosis through up-regulating ACSL4 expression. Overexpression of hsa-miR-4291 or knockdown of ACSL4 reversed the effect of circLMO1 on facilitating ferroptosis and repressing cervical cancer cell proliferation and invasion.
Survival: -
Supported No.:
 1
Description:

CircLMO1 acted as a tumor suppressor of cervical cancer by regulating miR-4291/ACSL4-mediated ferroptosis, and could be a promising biomarker for the clinical management of cervical cancer.
Other information
Title:

Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis.

Journal: Sci Rep
Published: 2022/3/25
PubMed ID: 35322101