circRNA basic information
circBase ID: -
Name: hsa_circ_LAMA3
Synonym: circLAMA3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: human normal urothelial cells (SV-HUC-1), human bladder cancer cell lines (RT4, T24, J82, UM-UC-3, TCCSUP)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: functional experiments demonstrated that circLAMA3 significantly inhibited the proliferation, migration, and invasion of bladder cancer cells and inhibited bladder cancer growthin vivo.
Molecular mechanism: circLAMA3 directly binds to and promotes the degradation of MYCN mRNA, thereby reducing the MYCN protein expression in bladder cancer cells. Decreased expression of the MYCN protein inhibits the promoter activity and expression of CDK6. Ultimately, circLAMA3 affects DNA replication by downregulating CDK6, resulting in G0/G1 phase arrest and inhibition of bladder cancer proliferation.
Survival: -
Supported No.:
 1
Description:

we report a potential novel regulatory mechanism via which a circRNA directly binds an mRNA and thereby regulates its fate. Moreover, circLAMA3 significantly affects the progression of bladder cancer and has potential as a diagnostic biomarker and therapeutic target for bladder cancer.
Other information
Title:

Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA.

Journal: Mol Ther Oncolytics
Published: 2022/3/24
PubMed ID: 35317525