circRNA basic information
circBase ID: hsa_circ_0101802
Name: -
Synonym: Circ_0101802
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human intestinal epithelial cell line (NCM460), CRC cell lines (HCT116, HCT8, SW480), HEK293T, HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DVL3
Associated microRNA: hsa-miR-665
Biological function: The expression of DVL3 and circ_0101802 was elevated in CRC tissues and cell lines, and high levels of DVL3 and circ_0101802 were closely associated with short survival time of CRC patients. Circ_0101802 silencing restrained the proliferation, migration, and tube formation abilities and induced the apoptosis of CRC cells. Circ_0101802 silencing-induced anti-tumor effects in CRC cells were partly reversed by DVL3 overexpression.
Molecular mechanism: hsa-miR-665 was an intermediary molecule between circ_0101802 and DVL3, and circ_0101802 could positively regulate DVL3 protein expression by sponging hsa-miR-665 in CRC cells. DVL3 overexpression partly overturned hsa-miR-665 overexpression-mediated anti-tumor effects in CRC cells. Circ_0101802 knockdown significantly suppressed xenograft tumor growth in vivo.
Survival: poor
Supported No.:
 3
Description:

circ_0101802 contributed to CRC progression by targeting miR-665/DVL3 signaling.
Other information
Title:

Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling.

Journal: Biochem Genet
Published: 2022/3/23
PubMed ID: 35314912