circRNA basic information
circBase ID: hsa_circ_0007142
Name: hsa_circ_DOCK1
Synonym: circ_0007142
Host Gene: hsa-miR-494-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ESCC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LASP1
Associated microRNA: hsa-miR-494-3p
Biological function: Circ_0007142 was upregulated in DDP-resistant ESCC tissues and cells. Circ_0007142 knockdown improved DDP sensitivity, induced cell apoptosis and hampered cell proliferation and invasion in DDP-resistant ESCC cells.
Molecular mechanism: Circ_0007142 functioned as the sponge for hsa-miR-494-3p and hsa-miR-494-3p inhibition reversed the impacts of circ_0007142 knockdown on DDP resistance, cell apoptosis, proliferation, and invasion. LASP1 was a target of hsa-miR-494-3p, and the effects on DDP resistance, cell apoptosis, growth, and invasion mediated by LASP1 downregulation were rescued by hsa-miR-494-3p inhibition. Moreover, circ_0007142 knockdown enhanced DDP sensitivity in vivo.
Survival: -
Supported No.:
 1
Description:

Circ_0007142 improved DDP resistance of ESCC by upregulating LASP1 via sponging miR-494-3p.
Other information
Title:

Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis.

Journal: J Clin Lab Anal
Published: 2022/3/22
PubMed ID: 35312115