circRNA basic information
circBase ID: hsa_circ_0072008
Name: hsa_circ_MYO10
Synonym: circ_0072008
Host Gene: hsa-miR-1305
 
 
 
Disease basic information
DO ID:
 3744
DO name: cervical squamous cell carcinoma
Disease details: cervical squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CESC cell lines
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: helicase,
Associated microRNA: hsa-miR-1305
Biological function: The levels of circ_0072008 and HELLS were upregulated, and the miR-1305 level was decreased in CESC tissues in contrast to that in normal tissues. For functional analysis, silencing circ_0072008 inhibited cell proliferation and cell migration, whereas enhanced cell apoptosis in CESC cells.
Molecular mechanism: circ_0072008 acted as a hsa-miR-1305 sponge to regulate the level of HELLS. Moreover, hsa-miR-1305 was confirmed to repress the progression of CESC cells by suppressing HELLS. Meanwhile, knockdown of circ_0072008 inhibited CESC cells growthin vivo.
Survival: -
Supported No.:
 1
Description:

circ_0072008 facilitated CESC cell proliferation, migration, and invasion through increasing HELLS expression by regulating miR-1305, which also offered an underlying targeted therapy for CESC treatment.
Other information
Title:

Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis.

Journal: Bioengineered
Published: 2022/3/22
PubMed ID: 35311456