circRNA basic information
circBase ID: hsa_circ_0077837
Name: hsa_circ_EPB41L2
Synonym: circ_0077837
Host Gene: hsa-miR-1178-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: BEAS-2B (bronchial epithelial line), NSCLC lines (H1650, H1975, NCI-H1359, HCC827, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: APITD1
Associated microRNA: hsa-miR-1178-3p
Biological function: Hsa_circ_0077837 and APITD1 expression were suppressed in NSCLC tissues and cells, and miR-1178-3p level was promoted. High amount of hsa_circ_0077837 intensely prevented cell proliferation, migration, and invasion, promoted cell apoptosisin vitro, and delayed tumor growth in mice.
Molecular mechanism: Further analysis indicated that hsa_circ_0077837 acted as a hsa-miR-1178-3p sponge to stabilize APITD1, the target of hsa-miR-1178-3p. Mechanistically, we discovered that hsa_circ_0077837 could prevent proliferation, viability, migration, and invasion of NSCLC cells through stimulating the hsa-miR-1178-3p/APITD1 pathway.
Survival: -
Supported No.:
 2
Description:

Collectively, our findings validated that hsa_circ_0077837 served as a miR-1178-3p sponge by targeting APITD1 that alleviated NSCLC progression.
Other information
Title:

hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis.

Journal: J Oncol
Published: 2022/3/22
PubMed ID: 35310916