circRNA basic information
circBase ID: -
Name: hsa_circ_Satb1
Synonym: Circ_Satb1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3328
DO name: temporal lobe epilepsy
Disease details: mesial temporal lobe epilepsy
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: mouse neuroblastoma cell line (Neuro-2a, ATCC)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: We report 333 differentially expressed (DE) circRNAs between healthy individuals and mTLE patients, of which 23 circRNAs displayed significant adjustedp-values following multiple testing correction. Interestingly, hippocampal expression of circ_Satb1, a circRNA derived from special AT-rich sequence binding protein 1 (SATB1), is decreased in both mTLE patients and in experimental epilepsy.
Molecular mechanism: circ_Satb1 displays dynamic patterns of neuronal expressionin vitroandin vivo. Further, circ_Satb1-specific knockdown using CRISPR/CasRx approaches in hippocampal cultures leads to defects in dendritic spine morphology, a cellular hallmark of mTLE.
Survival: -
Supported No.:
 1
Description:

our results identify a novel epilepsy-associated circRNA with disease-specific expression and previously unidentified cellular effects that are relevant for epileptogenesis.
Other information
Title:

Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.

Journal: Front Mol Neurosci
Published: 2022/3/22
PubMed ID: 35310884