circRNA basic information
circBase ID: hsa_circ_0078767
Name: hsa_circ_FAM120B
Synonym: CircRNA_0078767
Host Gene: hsa-miR-330-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: human osteosarcoma cell line (U2OS, SaOS-2, HOS), normal osteoblast cell line (hFOB 1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-3p
Biological function: circ_0078767-related ceRNA mechanism in osteosarcoma was studied. Bioinformatics tools primarily identified differentially expressed circRNAs and their downstream miRNAs in osteosarcoma, implying the potential interaction between circ_0078767, miR-330-3p, and cyclin-dependent kinase 14 (CDK14) in this malignancy, which were further verified by means of RNA immunoprecipitation, RNA pull-down, and dual-luciferase reporter gene assays. Aberrant abundance of circ_0078767 was found in both osteosarcoma tissues and cells, relating to dismal prognosis in patients with osteosarcoma.
Molecular mechanism: circ0078767 strengthened the proliferation, invasiveness, and migration of osteosarcoma cells, which could be neutralized by hsa-miR-330-3p. Additionally, hsa-miR-330-3p targeted and decreased CDK14 expression whereby motivating the malignant phenotypes of osteosarcoma cells. Through in vivo experiments, we further confirmed that circ_0078767 targeted hsa-miR-330-3p to upregulate CDK14, whereby strengthening the in vivo tumorigenic and metastatic ability of osteosarcoma cells.
Survival: poor
Supported No.:
 3
Description:

Circ_0078767 promotes the occurrence and development of osteosarcoma by upregulating CDK14 in a miR-330-3p-dependent manner.
Other information
Title:

CircRNA_0078767 promotes osteosarcoma progression by increasing CDK14 expression through sponging microRNA-330-3p.

Journal: Chem Biol Interact
Published: 2022/3/22
PubMed ID: 35307379