circRNA basic information
circBase ID: hsa_circ_0008797
Name: hsa_circ_GSK3B
Synonym: circ_0008797
Host Gene: hsa-miR-301a-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SOCS2.
Associated microRNA: hsa-miR-301a-3p
Biological function: circ_0008797 was low expressed in NSCLC tissues and cell lines, associating with poor outcome (p <.05). circ_0008797 was mainly expressed in NSCLC cells cytoplasm. circ_0008797 inhibited proliferation, migration, invasion, and glycolysis, but enhanced apoptosis of NSCLC cells (p <.05).
Molecular mechanism: circ_0008797 attenuated malignant phenotype of NSCLC cells by sponging hsa-miR-301a-3p. circ_0008797 facilitated SOCS2 expression by sponging hsa-miR-301a-3p. SOCS2 knockdown partially reversed the inhibitory effect of hsa-miR-301a-3p inhibition on NSCLC cells malignant phenotype (p <.05). circ_0008797 attenuated NSCLC prolifearion and metastasis in vivo (p <.05).
Survival: -
Supported No.:
 1
Description:

circ_0008797 attenuates NSCLC proliferation, metastasis and aerobic glycolysis by sponging miR-301a-3p/SOCS2.
Other information
Title:

circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2.

Journal: Environ Toxicol
Published: 2022/3/20
PubMed ID: 35305058